Yogesh Kolhe

Project Title: Validation of novel putative substrates of Matriptase identified through bioinformatics approach and their importance in cell adhesion and invasion.

Description: Our project involves validating the novel putative substrates of matriptase that were identified through bioinformatics approach. So far the only known substrates of matriptase are uPA1, HGF/SF2, PAR-23 G-protein coupled receptor Trask. These proteins have been implicated in remodeling of extra cellular matrix and thereby providing an interesting link between matriptase and cell adhesion and motility. Matriptase is a type II serine protease that is found in normal as well as cancerous cells. Under normal conditions, matriptase regulates activation of key components of ECM, like. Thus it plays an indirect role in regulating in cell adhesion and motility.